TRZ selectively inhibits neuronal reuptake of serotonin and is an antagonist of 5-HT 2A. It is somewhat useful in treating PTSD, but the evidence is minimal. Trazodone (TRZ) is a different class of antidepressants (serotonin-2 antagonist/reuptake inhibitors), approved for the treatment of major depression. The selective serotonin reuptake inhibitors (SSRIs) are the gold standard in the pharmacological treatment of PTSD patients, but they sometimes do not respond to SSRIs. Moreover, during the pandemic, HCWs experienced significantly great fear, ongoing arousal symptoms, and job dissatisfaction. PTSD is a severe psychiatric disorder and is particularly insidious in HCWs as, and surprisingly, they are reluctant to seek help. The trauma-related stress symptoms in HCWs are common, and several studies investigated the impact of post- traumatic stress on HCWs, suggesting that they are at high risk of developing post-traumatic stress disorder (PTSD), adjustment disorders, and other trauma-related disorders. However, healthcare workers (HCWs) paid the higher price of this pandemic in terms of deaths, contagions, and psychological well-being. Keywords: Healthcare workers COVID-19 PTSD Serotonin uptake inhibitors Trazodone Add-onĬOVID-19 represents a significant stress factor for all people worldwide. In the present article, we reported on two cases of HCWs directly involved in the treatment of COVID-19 patients who showed selective serotonin reuptake inhibitor-resistant PTSD, which was successfully treated with extended-release trazodone TRZ Contramid Ⓡ add-on. The early diagnosis and timely treatment of PTSD in HCWs may restore well-being and significantly impact health services functioning, reducing burnout, days spent far from work, disrupted personal and team empowerment, and worse job performances. Studies suggest that this particular population is at increased risk of developing a severe post-traumatic stress disorder (PTSD). However, the healthcare workers (HCWs) have paid the higher price of this pandemic in terms of fatalities, contagions, and psychological well-being. Abstract COVID-19 represents a significant stress factor for all people worldwide due to several factors, including quarantine, lockdowns, fear of contagion, deaths, and other traumatic events.
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